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Grantham Distance & BLOSUM62 โ€” PM5 Evaluator

ACMG PM5 criterion  ยท  Chemical similarity + evolutionary substitution frequency

PM5 โ€” Same Residue, Different Missense ACMG/AMP

Compare the previously reported pathogenic amino acid change with the variant under investigation at the same residue. Two complementary metrics: Grantham distance (chemical properties) and BLOSUM62 (evolutionary substitution frequency).

Known Pathogenic
The missense change seen in a known P/LP variant at this codon
Variant Under Investigation
The missense change in your variant at the same codon
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Select two amino acids above to calculate Grantham distance & BLOSUM62 score